Epigenomics starts to make its mark
نویسندگان
چکیده
منابع مشابه
Epigenomics of Ovarian Cancer and Its Chemoprevention
Ovarian cancer is a major cause of death among gynecological cancers and its etiology is still unclear. Currently, the two principle obstacles in treating this life threatening disease are lack of effective biomarkers for early detection and drug resistance after initial chemotherapy. Similar to other cancers, the initiation and development of ovarian cancer is characterized by disruption of on...
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Purpose — To report on the impact and cost/benefit of implementing three EPrints digital repositories at the University of Otago, and to encourage others to follow suit. Design/methodology/approach — Three repositories were successfully implemented at the University of Otago using existing commodity hardware and free open source software. The first pilot repository was implemented within ten da...
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www.landesbioscience.com Cell Cycle 3451 Epigenomic analyses are used for many applications, including discovering gene regulatory mechanisms, characterizing non-genetic transmission modes of adaptive and disease traits, identifying and detecting disease biomarkers, and for drug discovery, as epigenome modifying therapeutics are under development for therapeutic benefit. Epigenomic testing migh...
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Small nucleolar RNAs direct the location of certain methylations in ribosomal RNA by direct base pairing; although evolutionarily conserved, the physiological significance of these modifications remains unclear.
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Decades of research have uncovered much of the molecular machinery responsible for establishing and maintaining proper gene transcription patterns in eukaryotes. Although the composition of this machinery is largely known, mechanisms regulating its activity by covalent modification are just coming into focus. Here, we review several cases of ubiquitination, sumoylation, and acetylation that lin...
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ژورنال
عنوان ژورنال: Nature
سال: 2014
ISSN: 0028-0836,1476-4687
DOI: 10.1038/508022a